NSF SBIR/STTR (America's Seed Fund powered by NSF) vs Seed Enterprise Investment Scheme (SEIS) (2026): Which Is Better for Startups?
Both are startup grants. Here is how NSF SBIR/STTR (America's Seed Fund powered by NSF) and Seed Enterprise Investment Scheme (SEIS) compare on what a startup gets, who qualifies and how to apply, and which one we would pick.
NSF SBIR/STTR (America's Seed Fund powered by NSF)
Up to $2 million of zero-equity seed funding from NSF for deep-tech startups, starting with a short Project Pitch.
8.5 /10
Pricing: Up to $2M in credits & perks
Pros
- Zero equity, up to $2 million
- Short Project Pitch before any heavy paperwork
- Programme staff give feedback
Cons
- Excludes companies majority-owned by VC or PE firms
- Needs genuine technical risk, not just a product build
Seed Enterprise Investment Scheme (SEIS)
UK tax relief for your investors on up to GBP 250,000 of seed shares, which makes early rounds much easier to raise.
8.0 /10
Pricing: Free to join
Pros
- Makes UK angel rounds much easier to close
- Advance assurance gives investors confidence
- Open all year
Cons
- Not a grant: the benefit goes to investors
- Strict rules for three years after the investment
NSF SBIR/STTR (America's Seed Fund powered by NSF) vs Seed Enterprise Investment Scheme (SEIS) at a glance
| NSF SBIR/STTR (America's Seed Fund powered by NSF) | Seed Enterprise Investment Scheme (SEIS) | |
|---|---|---|
| Editor score | 8.5 / 10 | 8.0 / 10 |
| Pricing model | Free | Free |
| What you get | Up to $2M in credits & perks | Free to join |
| Who qualifies | US small business under 500 employees, 51%+ owned by US citizens or permanent residents, PI majority-employed by the company, R&D in the US; no majority VC/PE ownership; invitation via Project Pitch required. | UK-established company with gross assets up to GBP 350,000, under 25 FTE employees, qualifying trade under 3 years old; max GBP 250,000 raised under SEIS. |
| Partner code needed | No | No |
| Steps it helps with | raise funding, claim startup credits | raise funding, claim startup credits |
| Who it is for | Pre-seed, Seed stage, AI startups, Climate & energy, Health & bio | Pre-seed, Seed stage, Solo founders, Any stage |
| Reader upvotes | 0 | 0 |
| Best for | nsf, sbir, deep tech | seis, tax relief, angel investment |
Our pick
NSF SBIR/STTR (America's Seed Fund powered by NSF) edges it with a score of 8.5 versus 8.0. NSF SBIR/STTR (America's Seed Fund powered by NSF) is the better fit if you value: zero equity, up to $2 million, short project pitch before any heavy paperwork. Choose Seed Enterprise Investment Scheme (SEIS) instead if you need: makes uk angel rounds much easier to close, advance assurance gives investors confidence. Many startups can claim both: see credits by value.
Other startup grants to consider
Full ranking →America's Seed Fund (SBIR/STTR) 🎁 ProgramFree
Equity-free US federal R&D awards from 11 agencies, from proof of concept (Phase I) to prototype (Phase II).
EIC Accelerator 🎁 ProgramFree
Grant of up to EUR 2.5 million (about $2.9 million) for deep-tech startups and SMEs, with optional EIC equity.
SR&ED Tax Incentive (Canada) 🎁 ProgramFree
Refundable 35% R&D tax credit for Canadian-controlled private corporations on up to C$6 million of R&D a year.
R&D Tax Incentive (Australia) 🎁 ProgramFree
Refundable R&D tax offset of your company tax rate plus 18.5% for Australian companies with turnover under A$20 million.